New ISPE test: in vitro evaluation of anti pollution efficacy

The epidermis provides a barrier not only to numerous pathogens, but also to environmental damages caused by air pollution.
Several substances of proven toxicity such as polycyclic aromatic hydrocarbons are known air pollutants. The most studied of these substances is benzo[a]pyrene. This pollutant is easily absorbed and is rapidly distributed to the tissues, where it exerts its toxic action inducing the formation of Reactive Oxygen Species (ROS), able to cause damages to the cells.
This problem has prompted the cosmetic industry to formulate products that can protect the epidermis from pollutants by limiting the pro-oxidation activity, without affecting the normal functions of the skin.
Therefore, it’s essential to carry out tests to support the anti-pollution claim of a cosmetic product before its market release.
The anti-pollution efficacy of the product is evaluated in vitro through its ability to reduce ROS formation in keratinocytes after the stimulation with benzo[a]pyrene.
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